What does this research mean for the field?

Chronic tobacco smokers exhibit higher structural-functional coupling in the frontoparietal control network compared to nonsmokers, though this network-specific alteration is statistically weak and does not survive multiple-comparison correction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate whether chronic tobacco smokers demonstrate altered coupling between brain structural and functional connectivity across canonical large-scale networks.

September 10, 2026Network NeuroscienceOpen Access

Increased brain structural–functional coupling in the frontoparietal control network of chronic tobacco smokers

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To evaluate whether chronic tobacco smokers demonstrate altered coupling between brain structural and functional connectivity across canonical large-scale networks.
Assessed multimodal MRI scans from 47 chronic tobacco smokers and 46 nonsmokers.
Reconstructed structural connectivity using SIFT2-weighted tractography with inverse node-volume normalization and measured functional connectivity across seven Schaefer–Yeo networks.
Computed distance-corrected Spearman correlations between structural and functional edge weights across network densities of 10%–30% and parcellation scales of 246–446 nodes.
Smokers showed higher structural–functional coupling in the frontoparietal control network across tested densities and parcellations, although this increase did not survive multiple-comparison correction.
Coupling changes in dorsal attention and subcortical networks emerged only at select resolutions and remained inconsistent across parcellations.
Frontoparietal control network coupling within smokers showed no significant correlation with smoking exposure, nicotine dependence, or trait impulsivity.

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Implication

Comparative neuroimaging study finds increased frontoparietal control network structural–functional coupling in chronic tobacco smokers, indicating network-specific brain alterations.

Cite This Study

Monsivais et al. (2026) studied this question.

synapsesocial.com/papers/6aa27be758559d80afc756fa https://doi.org/10.1162/netn.a.606

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Implication

Comparative neuroimaging study finds increased frontoparietal control network structural–functional coupling in chronic tobacco smokers, indicating network-specific brain alterations.

Increased brain structural–functional coupling in the frontoparietal control network of chronic tobacco smokers

Key Points

Discussion

Implication

Cite This Study

Increased brain structural–functional coupling in the frontoparietal control network of chronic tobacco smokers

Key Points

Discussion

Implication

Cite This Study