What does this research mean for the field?

Ceramide-1-phosphate (C1P) regulates critical cellular processes and disease pathogenesis through direct interactions with specific protein targets, including enzymes, lipid transfer proteins, and signaling effectors. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Summarize current scientific evidence regarding direct interactions between ceramide-1-phosphate (C1P) and major regulatory proteins in cell physiology and disease pathogenesis.

September 10, 2026Biochemistry and Cell Biology

Ceramide 1-phosphate binding proteins: emerging regulators of cell physiology and disease

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Authors

AGAntonio Gomez-MuñozUniversity of the Basque Country ABAsier Benito-VicenteUniversity of the Basque Country KUKepa B. UribeUniversity of the Basque Country

Discussion

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Implication

Narrative review demonstrates how ceramide 1-phosphate directly modulates eight major regulatory proteins, highlighting therapeutic targets for inflammation, cancer, and metabolic disease.

Key Points

Summarize current scientific evidence regarding direct interactions between ceramide-1-phosphate (C1P) and major regulatory proteins in cell physiology and disease pathogenesis.
Synthesized molecular and biochemical literature on direct ceramide-1-phosphate (C1P) protein-binding interactions and downstream signaling pathways.
Analyzed eight specific C1P-interacting proteins: ASMase, SPT, cPLA2α, Gi-coupled receptors, CPTP, SMPDL3b, annexin A2-p11, and KEAP1.
Direct C1P binding modulates eight major target proteins to govern cell survival, inflammation, cell migration, oxidative stress, glucose uptake, and adipogenesis.
C1P-protein interactions regulate critical signaling cascades, including the PI3K/Akt, MEK/ERK1-2, and SMS/PKCα pathways.
Molecular mapping of C1P binding sites provides a rational framework to therapeutically target sphingolipid signaling in metabolic disorders, cancer, and chronic inflammation.

Cite This Study

Gomez-Muñoz et al. (2026) studied this question.

synapsesocial.com/papers/6aa27c0f58559d80afc75a02 https://doi.org/10.1139/bcb-2026-0193

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Implication

Narrative review demonstrates how ceramide 1-phosphate directly modulates eight major regulatory proteins, highlighting therapeutic targets for inflammation, cancer, and metabolic disease.