Narrative review reveals frequent pulmonary vascular and right ventricular dysfunction in ARDS, highlighting the need for targeted therapies addressing patient heterogeneity.
Key Points
To review the pathological mechanisms of cardiovascular derangements in acute respiratory distress syndrome (ARDS) and evaluate potential targeted therapeutic approaches.
Synthesized biological, pathological, and clinical findings regarding pulmonary vascular and cardiac involvement in ARDS.
Evaluated current management challenges related to hemodynamic impairment, mechanical ventilation, and patient biological heterogeneity.
Pulmonary vascular dysfunction occurs frequently despite standard lung-protective ventilation and strongly correlates with right ventricular failure and increased mortality.
Cardiovascular and alveolar pathologies are clinically intertwined, posing complex therapeutic challenges with few targeted interventions proven to improve clinical outcomes.
Differentiating biological subphenotypes in ARDS provides an emerging strategy to match specific cardiovascular mechanisms with targeted treatments.