Clinical review demonstrates improved headache response with early acute therapy in migraine, indicating nonopioids and triptans reduce pain recurrence.
Key Points
Review optimal acute pharmacological interventions for migraine headaches based on pain intensity and the timing of administration.
Evaluated acute clinical treatment approaches stratified by migraine pain severity and associated gastrointestinal symptoms.
Assessed the utility of oral nonopioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and triptans.
Initiating treatment while migraine pain remains mild to moderate improves overall clinical response and reduces the rate of headache recurrence.
Oral nonopioid analgesics, including NSAIDs or acetaminophen, adequately control mild to moderate migraine pain in the absence of severe nausea or vomiting.
Escalation with a triptan is recommended when moderate to severe migraine pain fails to resolve with nonopioid analgesics alone.