What does this research mean for the field?

Giant cell arteritis can occur concurrently with PLA2R-positive membranous nephropathy, suggesting potential overlapping immunological pathways that respond to corticosteroid therapy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the clinical presentation, diagnosis, and management of concurrent giant cell arteritis and anti-PLA2R-positive membranous nephropathy in an older patient.

September 10, 2026RheumatoOpen Access

Concurrent Giant Cell Arteritis and Anti-PLA2R-Positive Membranous Nephropathy: A Case Report

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Authors

KAKudret ArslanTemple University GBGerald J. BerryHeart Failure & Transplant JHJared HasslerTemple University

Discussion

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Implication

Case report reveals concurrent giant cell arteritis and anti-PLA2R membranous nephropathy in an older male, suggesting potential overlapping autoimmune pathways.

Key Points

To describe the clinical presentation, diagnosis, and management of concurrent giant cell arteritis and anti-PLA2R-positive membranous nephropathy in an older patient.
Clinical, biochemical, and histopathological evaluation of a 63-year-old male presenting with systemic inflammatory symptoms and nephrotic-range proteinuria (N=1).
Immunohistological confirmation of M-type phospholipase A2 receptor (PLA2R) in renal subepithelial immune deposits and therapeutic monitoring during corticosteroid treatment.
Diagnostic evaluation identified concurrent giant cell arteritis and membranous nephropathy with subepithelial PLA2R-positive deposits, accompanied by preserved renal function.
Treatment with corticosteroid therapy induced complete clinical and biochemical remission of both vascular and renal conditions.

Cite This Study

Arslan et al. (2026) studied this question.

synapsesocial.com/papers/6aa27c3058559d80afc75e86 https://doi.org/10.3390/rheumato6030021

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September 10, 2026RheumatoOpen Access

Concurrent Giant Cell Arteritis and Anti-PLA2R-Positive Membranous Nephropathy: A Case Report

View Full Paper

Ask AI

Bookmark

Authors

KAKudret ArslanTemple University GBGerald J. BerryHeart Failure & Transplant JHJared HasslerTemple University

Discussion

Member takes

Implication

Case report reveals concurrent giant cell arteritis and anti-PLA2R membranous nephropathy in an older male, suggesting potential overlapping autoimmune pathways.

Key Points

To describe the clinical presentation, diagnosis, and management of concurrent giant cell arteritis and anti-PLA2R-positive membranous nephropathy in an older patient.
Clinical, biochemical, and histopathological evaluation of a 63-year-old male presenting with systemic inflammatory symptoms and nephrotic-range proteinuria (N=1).
Immunohistological confirmation of M-type phospholipase A2 receptor (PLA2R) in renal subepithelial immune deposits and therapeutic monitoring during corticosteroid treatment.
Diagnostic evaluation identified concurrent giant cell arteritis and membranous nephropathy with subepithelial PLA2R-positive deposits, accompanied by preserved renal function.
Treatment with corticosteroid therapy induced complete clinical and biochemical remission of both vascular and renal conditions.

Cite This Study

Arslan et al. (2026) studied this question.

synapsesocial.com/papers/6aa27c3058559d80afc75e86 https://doi.org/10.3390/rheumato6030021

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