What does this research mean for the field?

Surgical fasciectomy and collagenase injection provide comparable 2-year outcomes for recurrent Dupuytren contracture, but surgery is associated with more severe adverse events. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To compare the efficacy and safety of surgical fasciectomy versus collagenase injection for the treatment of recurrent Dupuytren contracture.

September 10, 2026Plastic & Reconstructive Surgery

Surgical Fasciectomy Versus Collagenase Injection for Recurrent Dupuytren Contracture: A Randomized Controlled Trial

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Authors

JNJesper Nordenskjöld DEDavid Eckerdal ALAnna Lauritzson

Discussion

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Overview

Randomized trial finds no significant difference in two-year extension between collagenase and fasciectomy for recurrent Dupuytren contracture, indicating collagenase carries fewer severe risks.

Key Points

To compare the efficacy and safety of surgical fasciectomy versus collagenase injection for the treatment of recurrent Dupuytren contracture.
Single-center randomized controlled trial enrolling 59 patients with recurrent Dupuytren contracture randomly allocated to surgical fasciectomy (N=28) or collagenase injection (N=31).
Primary endpoints were the change in total active extension deficit (TAED) at 12 weeks from baseline and the rate of re-recurrence (defined as TAED worsening of ≥20° from 12 weeks to 2 years).
Mean TAED improvement from baseline was 52° in the fasciectomy group versus 49° in the collagenase group at 12 weeks (adjusted mean difference -1°; 95% CI, -9 to 8), and 47° versus 34° at 2 years (adjusted mean difference -8°; 95% CI, -23 to 7).
Re-recurrence occurred in 14.8% of patients receiving fasciectomy versus 27.6% receiving collagenase (RR 1.9; 95% CI, 0.6 to 5.6).
Early disability worsened at 3 weeks only in the fasciectomy group (QuickDASH adjusted mean difference -11.7; 95% CI, -18.5 to -5.0), and surgery led to 1 digital nerve laceration and 2 digital artery lacerations.

Cite This Study

Nordenskjöld et al. (2026) studied this question.

synapsesocial.com/papers/6aa27c4958559d80afc76011 https://doi.org/10.1097/prs.0000000000013450

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September 10, 2026Plastic & Reconstructive Surgery

Surgical Fasciectomy Versus Collagenase Injection for Recurrent Dupuytren Contracture: A Randomized Controlled Trial

View Full Paper

Ask AI

Bookmark

Authors

JNJesper Nordenskjöld DEDavid Eckerdal ALAnna Lauritzson

Discussion

Member takes

Overview

Randomized trial finds no significant difference in two-year extension between collagenase and fasciectomy for recurrent Dupuytren contracture, indicating collagenase carries fewer severe risks.

Key Points

To compare the efficacy and safety of surgical fasciectomy versus collagenase injection for the treatment of recurrent Dupuytren contracture.
Single-center randomized controlled trial enrolling 59 patients with recurrent Dupuytren contracture randomly allocated to surgical fasciectomy (N=28) or collagenase injection (N=31).
Primary endpoints were the change in total active extension deficit (TAED) at 12 weeks from baseline and the rate of re-recurrence (defined as TAED worsening of ≥20° from 12 weeks to 2 years).
Mean TAED improvement from baseline was 52° in the fasciectomy group versus 49° in the collagenase group at 12 weeks (adjusted mean difference -1°; 95% CI, -9 to 8), and 47° versus 34° at 2 years (adjusted mean difference -8°; 95% CI, -23 to 7).
Re-recurrence occurred in 14.8% of patients receiving fasciectomy versus 27.6% receiving collagenase (RR 1.9; 95% CI, 0.6 to 5.6).
Early disability worsened at 3 weeks only in the fasciectomy group (QuickDASH adjusted mean difference -11.7; 95% CI, -18.5 to -5.0), and surgery led to 1 digital nerve laceration and 2 digital artery lacerations.

Cite This Study

Nordenskjöld et al. (2026) studied this question.

synapsesocial.com/papers/6aa27c4958559d80afc76011 https://doi.org/10.1097/prs.0000000000013450

View Full Paper

Ask AI

Bookmark