DNA polymerase and DNA-dependent RNA polymerase carry out a similar complementary copying of a DNA template (Josse, Kaiser and Kornberg, 1961; Weiss and Nakamoto, 1961). However, the two reactions differ in the fate of the DNA helix which serves as template in the reaction. In the enzymatic synthesis of DNA, Wake and Baldwin (1962) have shown, using the dAT copolymer as a model DNA helix, that the strands of the parental DNA separate and are each incorporated into a progeny helix. This is consistent with the semi-conservative mode of replication of DNA found in vivo by Meselson and Stahl (1958).
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Chamberlin et al. (1963) studied this question.