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June 24, 2022MetabolitesOpen Access

Dissecting the Roles of Lipids in Preeclampsia

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Key result

Lipid metabolic abnormalities are linked to higher risk of preeclampsia development and progression.

Why the study?

Lipid metabolic abnormalities have emerged as potential risk factors for the development and progression of preeclampsia, but a comprehensive understanding of their roles is needed.

Design

Review

Authors

YYYang YuYWYixiao WangYLYan Lv

Discussion

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Overview

May inform preeclampsia risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.

Structured PICO

P
Population
Patients with preeclampsia

This review highlights the role of lipid dysregulation in the pathogenesis of preeclampsia and suggests lipid-targeting as a potential therapeutic strategy.

Cite This Study

Yu et al. (2022) conducted a review in Preeclampsia. Lipid metabolic abnormalities was evaluated. Lipid metabolic abnormalities and dysregulation of various lipid classes are potential risk factors for the development and progression of preeclampsia.

synapsesocial.com/papers/6aa27f02375ea2a2e2fdceb5https://doi.org/10.3390/metabo12070590
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Also Consider

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  1. 1Pre-eclampsia rates in the United States, 1980-2010: age-period-cohort analysis2013 · 965 citations
  2. 2Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature2020 · 19 citations
  3. 3Antibodies From Preeclamptic Patients Stimulate Increased Intracellular Ca <sup>2+</sup> Mobilization Through Angiotensin Receptor Activation2004 · 131 citations
  4. 4Preeclampsia—Pathophysiology and Clinical Presentations2020 · 875 citations
  5. 5Integrated Metabolomic and Lipidomic Analysis in the Placenta of Preeclampsia2022 · 71 citations