An on-line SFE/HPLC system incorporating a recirculating pump to achieve efficient mixing under static extraction conditions was developed to measure the solubility of different analytes in supercritical fluids. To test the system and method, the solubility of anthracene in supercritical CO 2 was measured and the results were quantitatively similar to those reported previously. The solubilities of neat sulfamethazine (SMZ) and sulfadimethoxine (SDM) were measured in supercritical carbon dioxide, supercritical fluoroform, and subcritical Freon 134A. Results showed that both drugs have significantly higher solubility in subcritical Freon 134A than in supercritical fluoroform or CO 2 .
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Ashraf‐Khorassani et al. (1997) studied this question.
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