Use of 1,1,1,2-Tetrafluoroethane (R-134a)-Expanded Liquids as Solvent Media for Ecoefficient Particle Design with the DELOS Crystallization Process

R-134a-expanded liquids have been used as solvent media for the straightforward crystallization of micron-sized crystalline powders using the depressurization of an expanded liquid organic solution (DELOS) procedure. The results, obtained with three different kinds of compounds aspirin, hexamethylenetetramine, and solvent blue 35 show that R-134-expanded liquids are suitable solvent media for material synthesis and processing at much lower working pressures (<1 MPa) than those required with compressed CO 2 (>15 MPa) and even CO 2 -expanded solvents (≈10 MPa).