Diastereoselective and Enantioselective Substitution Reactions of an Isoindoline-Borane Complex

All articles of this category The alkylation of N -methylisoindoline-borane complex is diastereoselective, the substitution occurring predominantly syn to the borane group. Use of the S BuLi-sparteine reagent mixture enables the reaction to be conducted enantioselectively, giving the chiral isoindoline-borane complexes in up to 89% ee. Both the relative and absolute configurations of the alkylation products were established by X-ray structure determinations. isoindoline - enantioselective metallation - (-)-sparteine - amine-borane complex