Key result
Kaempferol lowers fat weight and LDL while boosting HDL and glucose tolerance in obese diabetic mice.
Why the study?
The molecular mechanisms by which kaempferol regulates lipid and glucose metabolism were not fully understood.
Does Kaempferol improve lipid profile and glucose tolerance in Tsumura, Suzuki, Obese Diabetes mice?
Does Kaempferol improve lipid profile and glucose tolerance in Tsumura, Suzuki, Obese Diabetes mice?
Kaempferol improves metabolic syndrome symptoms in a mouse model by modulating lipid profiles and glucose tolerance, potentially via hepatic LDLR and ApoA1 expression and resistin reduction.
Kaempferol may improve metabolic markers in obese diabetic mice; hypothesis-generating for human translation.
Kaempferol (KPF) is a dietary polyphenol reported to have various beneficial effects on human health. However, its molecular mechanisms in regulating lipid and glucose metabolism are not fully understood. This study examined the effects of KPF on obesity, dyslipidemia, and diabetes in Tsumura, Suzuki, Obese Diabetes mice. The 6-week administration of KPF decreased fat weight, serum total cholesterol, and low-density lipoproteins (LDLs); increased high-density lipoproteins (HDLs); and improved glucose tolerance. Additionally, KPF increased LDL receptor (LDLR) and apolipoprotein A1 (ApoA1) gene expression and decreased serum resistin levels. These findings suggest that the decrease in LDL and the increase in HDL caused by KPF may be due to increases in hepatic LDLR and ApoA1 expression, respectively. Furthermore, it is possible that the improvement in glucose tolerance by KPF may occur via resistin reduction. These mechanisms may be parts of complex mechanism by which KPF improves metabolic syndrome.
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Ochiai et al. (2021) studied Metabolic syndrome (obesity, dyslipidemia, and diabetes). Kaempferol (KPF) was evaluated on Fat weight, serum total cholesterol, LDLs, HDLs, and glucose tolerance. Kaempferol administration for 6 weeks in Obese Diabetes mice decreased fat weight, total cholesterol, and LDLs, increased HDLs, and improved glucose tolerance.
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