Key result
JSP extract prevents cardiomyopathy in diabetic rats by lowering oxidative stress and apoptosis.
Why the study?
Diabetes mellitus leads to complications such as cardiomyopathy, motivating the assessment of therapeutic effects of phenolic acids extracted from Jasminum sambac leaves against diabetes-induced cardiomyopathy.
Does Jasminum sambac phenols extract improve cardiac biomarkers and oxidative stress in alloxan-induced diabetic rats?
Does Jasminum sambac phenols extract improve cardiac biomarkers and oxidative stress in alloxan-induced diabetic rats?
Phenolic extracts from Jasminum sambac leaves mitigate diabetic cardiomyopathy in a rat model by modulating oxidative stress and apoptosis.
Should not change clinical practice in diabetic cardiomyopathy; hypothesis-generating for phenolic extracts in translational cardiovascular models.
Diabetes mellitus is a chronic metabolic disorder defined as hyperglycemia and pancreatic β-cell deterioration, leading to other complications such as cardiomyopathy. The current study assessed the therapeutic effects of phenolic acids extracted from Jasminum sambac phenols of leaves (JSP) against diabetes-induced cardiomyopathy in rats. The rats were divided into four groups, with each group consisting of 20 rats. The rats were given intraperitoneal injections of alloxan monohydrate (150 mg/kg) to induce diabetes. The diabetes-induced groups (III and IV) received treatment for six weeks that included 250 and 500 mg/kg of JSP extract, respectively. In the treated rats, the results demonstrated that JSP extract restored fasting glucose, serum glucose, and hyperlipidemia. Alloxan induced cardiomyopathy, promoted oxidative stress, and altered cardiac function biomarkers, including cardiac troponin I, proBNP, CK-MB, LDH, and IMA. The JSP extract-treated rats showed improved cardiac function indicators, apoptosis, and oxidative stress. In diabetic rats, the mRNA expression of caspase-3, BAX, and Bcl-2 was significantly higher, while Bcl-2, Nrf-2, and HO-,1 was significantly lower. In the treated groups, the expression levels of the BAX, Nrf-2, HO-1, Caspase-3, and Bcl-2 genes were dramatically returned to normal level. According to our findings, the JSP extract prevented cardiomyopathy and heart failure in the hyperglycemic rats by improving cardiac biomarkers and lowering the levels of hyperlipidemia, oxidative stress, apoptosis, hyperglycemia, and hyperlipidemia.
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Umar et al. (2023) studied Diabetic cardiomyopathy (n=80). Jasminum sambac phenols of leaves (JSP) extract vs. Untreated diabetic rats was evaluated on Cardiac function biomarkers, oxidative stress, and apoptosis. JSP extract at doses of 250 and 500 mg/kg prevented cardiomyopathy in diabetic rats by improving cardiac biomarkers and lowering oxidative stress and apoptosis.
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