Answers are grounded in this paper and cite their sources.
AIM:To investigate the relationship between alanyl-glutamine (ALA-GLN) and glutathione (GSH) biosynthesis in hepatic protection.METHODS:Twenty male Wistar rats were randomly divided into two groups:one receiving standard parenteral nutrition (STD) and the other supplemented with or without ALA-GLN for 7 days. The blood and liver tissue samples were examined after 5-fluorouracil (5-FU) was injected peritoneally.RESULTS:The concentration measurements were significantly higher in ALA-GLN group than in STD group in serum GLN (687mol/L plus minus 50mol/L vs 505mol/L plus minus 39mol/L, P < 0.05), serum GSH (14mol/L plus minus 5mol/L vs 7mol/L plus minus 3mol/L, P <0.01) and in liver GSH content (6.9mol/g plus minus 2.5mol/g vs 4.4mol/g plus minus 1.6mol/g liver tissue, P <0.05). Rats in ALA-GLN group had lesser elevations in hepatic enzymes after 5-FU administration.CONCLUSION:The supplemented nutrition ALA-GLN can protect the liver function through increasing the glutathione biosynthesis and preserving the glutathione stores in hepatic tissue.
No takes yet. Share an insight, caveat, or question.
Yu Jianchun (1999) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: