Key result
Multimodal therapy fails to halt rapid progression of left atrial epithelioid angiosarcoma, with 8-month survival.
Case Report (n=1)
This case highlights the aggressive nature and high malignancy of left atrial epithelioid angiosarcoma, which can present with embolic strokes and has limited response to current therapies.
Prompt cardiac imaging warranted in recurrent embolic stroke with anemia; leaves open optimal therapy for metastatic cardiac angiosarcoma.
A 74-year-old man presented with recurrent cerebellar infarction and progressive anemia. The workup revealed a small jejunal tumor and a mobile mass in the left atrium. Urgent minimally invasive cardiac surgery was performed, and histopathology confirmed epithelioid angiosarcoma. Subsequent small bowel resection revealed a similar tumor. Despite chemotherapy and radiotherapy, bone metastases progressed, and the patient succumbed to the disease eight months postoperatively. The cardiac tumor was smaller than typically reported, suggesting early detection prompted by embolic events. Nevertheless, the clinical course was aggressive, highlighting the high malignancy of epithelioid angiosarcoma and the limited effectiveness of current therapies. Accumulation of further clinical experience is essential to improve outcomes in this rare cardiac tumor.
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Tamura et al. (2025) conducted a case report in Left atrial epithelioid angiosarcoma (n=1). Minimally invasive cardiac tumor resection and multimodal therapy was evaluated on Clinical outcome. Despite urgent minimally invasive surgical resection and multimodal therapy, the patient with left atrial epithelioid angiosarcoma experienced rapid disease progression and died eight months postoperatively.
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