Key result
Primary right heart tumors linked to ~275% higher recurrence and greater mortality vs left-sided tumors.
Why the study?
The clinical characteristics, surgical treatment, and long-term efficacy of primary right heart tumors needed investigation.
Do primary right heart tumors have different perioperative and long-term outcomes compared to left heart tumors after surgical resection?
Cohort (n=140)
Do primary right heart tumors have different perioperative and long-term outcomes compared to left heart tumors after surgical resection?
Absolute Event Rate: 21.4% vs 5.7%
p-value: p=0.002
Primary right heart tumors are associated with a higher incidence of malignancy, higher recurrence rates, and lower long-term survival compared to left heart tumors, despite a lower perioperative risk of systemic embolism.
Right heart tumors linked to more malignancy, recurrence, and lower survival vs left; leaves open whether tailored strategies improve outcomes in observational data.
INTRODUCTION: The aim of the study was to investigate the clinical characteristics, surgical treatment, and long-term efficacy of primary right heart tumors. METHODS: This study is retrospective analysis of the clinical data of 70 patients with primary right heart tumors admitted to our department between 1980 and 2022 (observation group) and 70 patients with left heart tumors during the same period (control group). The surgical treatment was performed under cardiopulmonary bypass after differential diagnosis by echocardiography, cardiac CTA, and PET-CT before the surgery. The perioperative characteristics, recurrence rate, and long-term survival rates of right heart tumor versus left heart tumor were compared. RESULTS: The most common pathological types of right heart tumors were myxoma (60%), lipoma (8.57%), and papillary elastofibroma (7.14%). During the perioperative period, there were 1 case of systemic embolism in the observation group, compared with 6 in the control group (p = 0.026), 13 cases of malignant tumor in the observation group versus 1 in the control group (p = 0.01). During the follow-up period, there were 15 cases of tumor recurrence and 17 cases of death in the observation group versus 4 (p = 0.002) and 7 in the control group (p = 0.006), comparatively. CONCLUSION: Compared with left heart tumors, primary right heart tumors had a higher incidence of malignant tumors and a lower risk of systemic embolism during perioperative period. During the follow-up period, primary right heart tumors had a higher rate of tumor recurrence and a lower long-term survival rate.
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Li et al. (2024) conducted a cohort in Primary heart tumors (n=140). Primary right heart tumors vs. Primary left heart tumors was evaluated on Tumor recurrence (p=0.002). Primary right heart tumors were associated with a higher rate of tumor recurrence (21.4% vs 5.7%, p=0.002) and death (24.3% vs 10.0%, p=0.006) compared to left heart tumors.
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