Key result
TAVR triggers fatal secondary Takotsubo syndrome in a patient with severe AS and congenital VSD.
Case Report (n=1)
No
Transcatheter aortic valve replacement in a patient with a preexisting ventricular septal defect can trigger Takotsubo syndrome due to acute intracardiac hemodynamic shifts.
Raises caution for TAVR in congenital VSD; case report leaves open causal confirmation in larger series.
The authors report the clinical case of secondary Takotsubo syndrome developed after transcatheter aortic valve replacement that was performed in compassionate manner in female patient with combination of congenital ventricular septal defect and acquired severe aortic stenosis. In the teams view, Takotsubo syndrome was triggered with profound changes of intracardial hemodynamics subsequent to iatrogenic impairment of preexisting interventricular shunt.
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Комлев et al. (2021) conducted a case report in Congenital ventricular septal defect and severe acquired aortic stenosis (n=1). Transcatheter aortic valve replacement was evaluated on Development of Takotsubo syndrome and clinical outcome. Transcatheter aortic valve replacement in a patient with a congenital ventricular septal defect and severe aortic stenosis triggered secondary Takotsubo syndrome and fatal acute heart failure.
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