Why the study?
Does morphologic grading of hepatic mitochondrial alteration correlate with clinical outcomes in patients with Reye's syndrome?
Observational (n=50)
Does morphologic grading of hepatic mitochondrial alteration correlate with clinical outcomes in patients with Reye's syndrome?
Electron microscopic grading of hepatic mitochondrial injury correlates with clinical severity and outcome in Reye's syndrome, suggesting potential prognostic utility.
Answers are grounded in this paper and cite their sources.
Mitochondrial grading may support prognosis in Reye syndrome; hypothesis-generating and should not yet change practice.
Mitochondrial alterations are known to be constantly associated with Reye's syndrome. Fifty-eight liver specimens from 50 patients who fulfilled the clinical and pathologic criteria were examined by electron microscopy. The degree of mitochondrial injury was graded I, II, and III according to the severity of the alteration of mitochondrial matrix. The results correlated well with clinical parameters--specifically initial clinical stage, peak clinical stage, and clinical outcome. Electron microscopic examination of hepatic mitochondria is therefore potentially useful in evaluating Reye's syndrome patients.
No takes yet. Share an insight, caveat, or question.
Chang et al. (1985) conducted an observational in Reye's syndrome (n=50). Morphologic grading of hepatic mitochondrial alteration was evaluated on Correlation with clinical parameters (initial clinical stage, peak clinical stage, and clinical outcome).
Synapse has enriched 10 related papers. Consider them for comparative context: