Why the study?
Left ventricular dysfunction remains common and associated with adverse prognosis after acute myocardial infarction despite primary PCI, prompting investigation into its predictors.
What are the echocardiographic and clinical predictors of left ventricular dysfunction in patients undergoing primary PCI for first anterior myocardial infarction?
Observational (n=50)
What are the echocardiographic and clinical predictors of left ventricular dysfunction in patients undergoing primary PCI for first anterior myocardial infarction?
p-value: p=<0.001
Tissue Doppler imaging parameters at discharge and 3 months are independent predictors of left ventricular dysfunction and remodeling after primary PCI for anterior STEMI.
May identify Tissue Doppler predictors of post-PCI LV dysfunction in anterior MI; hypothesis-generating and requires validation before clinical adoption.
Background: Primary percutaneous coronary intervention (PCI) has revolutionized the outcome and management of acute myocardial infarction. However, the occurrence of left ventricular dysfunction remains relatively common event following acute myocardial infarction and in associated with an adverse prognosis in these patients. this work aimed to investigate to the left ventricular dysfunction predictors following PCI for anterior myocardial infarction (AMI) using different parameters: Tissue Doppler imaging (TDI), Biomarkers (Troponin, CK-MB) and Echocardiography Methods: This research was conducted prospectively on 50 patients aged from 40 to 70 years old, presenting by first anterior myocardial infarction and treated with PCI. All cases were subjected to full history, full clinical examination, laboratory investigations, resting 12 leads electrocardiography, two dimensions echocardiography and tissue doppler imaging. Results: Highly statistically significant between EF baseline with EF on discharge and EF on discharge with after 3 months p-value was <0.001. Pre balloon dilatation, S wave of tissue Doppler imaging on discharge and S wave tissue Doppler imaging after 3 months were predictors for left ventricular systolic function. Conclusions: Persistent LV dysfunction following successful primary PCI is infrequent and is related to poor clinical outcomes at 3 months clinical follow-up. Tissue Doppler on discharge and after three months after myocardial infarction are independent predictors of LV dysfunction after anterior STEMI and can be used to predict occurrence of LV remodelling after 6 months.
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Darwesh et al. (2022) conducted an observational in Acute anterior myocardial infarction (n=50). Tissue Doppler imaging (S wave) was evaluated on Change in ejection fraction from baseline to discharge and at 3 months (p=<0.001).
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