Key result
Primary percutaneous coronary intervention in patients with acute myocardial infarction significantly improved mean left ventricular ejection fraction by 6.38% at 6 months compared to baseline.
Why the study?
Data on changes in LV function after revascularization were scarce in the authors' population, despite LV functional improvement being an important determinant of long-term prognosis after AMI.
Does primary percutaneous coronary intervention (PCI) improve left ventricular functional remodeling in patients with acute myocardial infarction?
Observational (n=188)
Blinded outcome assessment
No
Does primary percutaneous coronary intervention (PCI) improve left ventricular functional remodeling in patients with acute myocardial infarction?
Effect estimate: Mean difference 6.38
Absolute Event Rate: 46.17% vs 39.79%
p-value: p=<0.001
Primary PCI in patients with acute myocardial infarction is associated with significant improvements in left ventricular ejection fraction and dimensions at 6 months.
Supports potential LV remodeling benefit after primary PCI in AMI; leaves open causal effects in observational data.
Background: Improvement in left ventricular (LV) function after revascularization is an important determinant of long-term prognosis in a patient with acute myocardial infarction (AMI). However, data on the changes of LV function after revascularization are scarce in our population. Hence, this study was conducted to evaluate the changes in LV function and dimensions by echocardiography at 3 and 6 months after primary percutaneous coronary intervention (PCI). Materials and Methods: A total of 188 patients were recruited in this study who had undergone primary PCI. Patients with preexistent LV dysfunction, prior PCI, or with congenital heart disease were excluded. Echocardiography was performed at baseline (within 24 h of intervention), 3 months, and 6 months of intervention. Remodeling in terms of change in LV ejection fraction (LVEF), LV end-diastolic dimension (LVEDD), LV end-systolic dimension, and wall motion score index (WMSI) was evaluated. Results: < 0.001) at 6 months. Baseline LVEDD was 46.23 ± 3.86 mm which improved to 44.68 ± 2.81 mm at 6 months. Basal WMSI decreased by -0.09 ± 0.08 and -0.13 ± 0.09 at 3 and 6 months, respectively, after revascularization. Conclusions: Primary PCI is the recommended mode of reperfusion in patients with AMI. It reduces infarct size, maintains microvascular integrity and preserves LV systolic function hence improving LV function.
No takes yet. Share an insight, caveat, or question.
Batra et al. (2022) conducted an observational in Acute myocardial infarction (AMI) (n=188). Primary percutaneous coronary intervention (PCI) vs. Baseline was evaluated on Left ventricular ejection fraction (LVEF) at 6 months (Mean difference 6.38, p=<0.001). Primary percutaneous coronary intervention in patients with acute myocardial infarction significantly improved mean left ventricular ejection fraction by 6.38% at 6 months compared to baseline.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: