Key result
Higher baseline LVEF linked to ~11% lower 1-month MACE risk.
Why the study?
Longitudinal changes in left ventricular systolic function after primary PCI for acute MI, categorized by culprit vessel, were not well characterized.
Does left ventricular strain improve post-PCI and predict major adverse cardiac events in patients with acute myocardial infarction?
Cohort (n=158)
No
Does left ventricular strain improve post-PCI and predict major adverse cardiac events in patients with acute myocardial infarction?
Odds Ratio: 0.89 (95% CI 0.78–0.976)
p-value: p=0.05
Global LV strain improves significantly one month after primary PCI for acute MI, but baseline LVEF and WMSI are better independent predictors of short-term MACE than LV strain.
Baseline LVEF may aid short-term MACE risk stratification after primary PCI for AMI; leaves open whether strain adds value beyond LVEF.
Background: This study aimed to assess the longitudinal changes in left ventricular (LV) systolic function among patients who underwent primary percutaneous coronary intervention (PCI) for acute myocardial infarction (MI), categorized by the affected vessel. Methods: A cohort study included 158 patients who received primary angioplasty for acute MI. Each patient had a baseline echocardiographic evaluation utilizing M-mode, two-dimensional measurements, and strain and strain rate assessments. Participants were monitored over a month to evaluate changes in LV systolic function. Results: After one-month post-revascularization, a noteworthy improvement in global LV strain was observed (p-value = 0.05). Patients who experienced major adverse cardiac events (MACE) showed a significant reduction in Left Ventricular Global Longitudinal Strain (LV GLS) compared to those without events. Additionally, values for the Wall Motion Score Index and LV end-systolic volume were substantially elevated in the MACE group versus the event-free group. Conclusion: The findings reveal an enhancement in LV systolic function, measured via speckle tracking echocardiography, exceeding that of left ventricular ejection fraction (LVEF) regardless of the culprit vessel. MACE was reported in 4.4% of the acute MI patients even after successful PCI. Baseline LV EF and Wall Motion Score Index were identified as independent predictors of MACE at the one-month follow-up, more so than LV strain.
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S et al. (2025) conducted a cohort in Acute myocardial infarction (n=158). Primary percutaneous coronary intervention (PCI) was evaluated on Major adverse cardiac events (MACE) at one month (OR 0.89, 95% CI 0.78-0.976, p=0.05). Baseline left ventricular ejection fraction was identified as an independent predictor of major adverse cardiac events at one-month follow-up (OR 0.89).
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