Key result
LV remodeling is linked to a ~19% absolute increase in 4-year major cardiac events.
Why the study?
It was unknown whether subtle changes in myocardial work indices predict LV remodeling and MACEs in patients with a first STEMI and preserved LVEF after successful PCI.
Do subtle changes in myocardial work indices assessed by 2D-STE predict left ventricular remodeling and MACEs in STEMI patients with preserved LVEF after successful primary PCI?
Case-Control (n=246)
No
Do subtle changes in myocardial work indices assessed by 2D-STE predict left ventricular remodeling and MACEs in STEMI patients with preserved LVEF after successful primary PCI?
Absolute Event Rate: 34% vs 15%
p-value: p=0.01
Non-invasive myocardial work indices assessed by 2D-STE, particularly global work efficiency, accurately predict post-MI LV remodeling and long-term MACEs in STEMI patients with preserved LVEF.
May support post-STEMI risk stratification with myocardial work indices; hypothesis-generating and requires prospective validation before clinical use.
The goal of this study was to assess whether subtle changes in myocardial work indices may predict left ventricular (LV) remodeling and major cardiac events (MACEs) in patients with a first ST-elevation acute myocardial infarction (STEMI) and preserved LVEF after successful myocardial revascularization with PCI. Methods. Consecutive STEMI patients in sinus rhythm and with an LV ejection fraction ≥ 50% following a successful PCI were recruited. Conventional and two-dimensional speckle tracking echocardiography (2D-STE) was conducted within 36 h of the PCI and 3 months later. Patients having an increase of more than 20% in LV diastolic volume were included in the LV remodeling group. MACEs were noted throughout a four-year period of follow-up. Results: The study comprised 246 STEMI patients with a mean age of 66; 72% of whom were men. In 24% (58) of the patients, LV remodeling developed. These patients were older, more frequently hypertensive, and had a smoking history. They also exhibited significantly lower baseline and 3-month values for the myocardial global index (GWI), global constructive work (GCW), and global myocardial efficiency (GWE). The cut-off values of 1670 mmHg% for GWI and 83% for GWE were predictive of LV remodeling (p < 0.0001). During the four-year follow-up period, 19% of STEMI patients experienced a MACE, involving 15% from non-LV remodelers and 34% from LV remodelers (p = 0.01). The cut-off values for baseline GWI of 1680 mmHg% and baseline GWE of 84% had the best accuracy in predicting MACEs. In conclusion, non-invasive myocardial work indices offered a reproducible and accurate method to predict post-MI LV remodeling and MACEs.
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Arnăutu et al. (2023) conducted a case-control in ST-elevation myocardial infarction (STEMI) with preserved LVEF (n=246). Left ventricular (LV) remodeling vs. No LV remodeling was evaluated on Major cardiac events (MACEs) (p=0.01). Baseline global work efficiency ≤84% and global work index ≤1680 mmHg% accurately predicted major cardiac events, which occurred more frequently in patients with LV remodeling (34% vs 15%, p=0.01).
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