The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol is associated with diabetic kidney disease: A cross-sectional study

Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio (NHHR) is a significant indicator of atherosclerosis. However, its association with diabetic kidney disease (DKD) remains unclear. This study aims to explore the relationship between NHHR and the prevalence of DKD among the U.S. adults using data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2020. Participants were selected based on the stringent inclusion and exclusion criteria. We utilized single-factor analysis, multivariate logistic regression, and smooth curve fitting to investigate the relationship between NHHR and DKD. Our study included 8,329 diabetic individuals, who were categorized into DKD and non-DKD groups based on the presence or absence of kidney damage. A significant difference in NHHR was observed between these groups. After adjusting for potential confounders, we found that NHHR was positively associated with the prevalence of DKD. Specifically, each one-unit increase in NHHR corresponded to a 6% rise in the prevalence of DKD, with this association remaining significant across stratified NHHR values. Threshold effect analysis revealed an inflection point at an NHHR of 1.75, beyond this point, each unit increase in NHHR was associated with a 7% increase in the prevalence of DKD. Subgroup analysis confirmed the robustness of these findings. Our study demonstrates a significant correlation between NHHR and DKD prevalence, suggesting that monitoring NHHR could be an effective strategy for reducing DKD prevalence.