Key result
Age-related increases in arterial stiffness are associated with metabolic syndrome components and inflammatory markers, with oxidative stress being independently associated with arterial stiffness specifically in individuals older than 45 years.
Cross-Sectional (n=4,318)
No
The determinants of arterial stiffness vary by age, with oxidative stress playing an independent role in individuals over 45 years old.
Should not yet change arterial stiffness evaluation; leaves open whether oxidative stress is a modifiable target after age 45.
AIM: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress. METHODS: A total of 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 y (n=1,413), 45-54 y (n=1,384), and 55-79 y (n=834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured. RESULTS: ), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19-34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35-44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45-54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55-79 y group. CONCLUSIONS: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.
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Kim et al. (2017) conducted a cross-sectional in Metabolic Syndrome and Arterial Stiffness (n=4,318). Age, metabolic syndrome components, and oxidative stress vs. Younger age and absence of metabolic risk factors was evaluated on Age-specific determinants of brachial-ankle pulse wave velocity (baPWV). Age-related increases in arterial stiffness are associated with metabolic syndrome components and inflammatory markers, with oxidative stress being independently associated with arterial stiffness specifically in individuals older than 45 years.
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