Key result
Fetuses with intrauterine growth restriction had a significantly higher mean pulmonary vein pulsatility index compared to normal fetuses (1.31 vs 0.83; P<0.001).
Why the study?
Is the pulmonary vein pulsatility index higher in fetuses with intrauterine growth restriction compared to normal fetuses?
Observational (n=43)
Is the pulmonary vein pulsatility index higher in fetuses with intrauterine growth restriction compared to normal fetuses?
Absolute Event Rate: 1.31% vs 0.83%
p-value: p=<0.001
Fetuses with intrauterine growth restriction exhibit a higher pulmonary vein pulsatility index, suggesting altered left atrial dynamics or left ventricular diastolic dysfunction.
OBJECTIVE: To test the hypothesis that the pulmonary vein pulsatility index (PVPI) is higher in fetuses with growth restriction (IUGR) than in normal fetuses. METHODS: Twenty-two fetuses with IUGR and twenty-one (21) fetuses with appropriate growth for gestational age from healthy mothers were studied. PVPI was calculated by Doppler echocardiography [maximal velocity (systolic or diastolic peak) - pre-systolic peak / mean velocity]. Obstetric ultrasound was used to assess fetal biometry and Doppler to assess the uterine, umbilical and middle cerebral arteries PI. Statistical analysis used t test and Pearson's correlation. RESULTS: Mean gestational age was 31.5 +/- 2.1 weeks in the control group and 31.4 +/- 3.1 weeks in IUGR (P = 0.91). The PI of uterine and umbilical arteries were higher in IUGR than in controls (P < 0.001). Mean PVPI in IUGR fetuses was 1.31 +/- 0.41, and in controls it was 0.83 +/- 0.11 (P < 0.001). CONCLUSION: The pulsatility index of pulmonary venous flow in fetuses with growth restriction is higher than in normal fetuses, probably as a result of left atrial dynamics alteration secondary or not to fetal left ventricular diastolic dysfunction.
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Bravo‐Valenzuela et al. (2014) conducted an observational in Intrauterine growth restriction (n=43). Intrauterine growth restriction vs. Appropriate growth for gestational age was evaluated on Pulmonary vein pulsatility index (PVPI) (p=<0.001). Fetuses with intrauterine growth restriction had a significantly higher mean pulmonary vein pulsatility index compared to normal fetuses (1.31 vs 0.83; P<0.001).
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