Key result
Pregnancies complicated by intrauterine fetal growth restriction were associated with significantly lower maternal cardiac output (4.6 vs 6.7 L) and higher total vascular resistance compared to normal pregnancies.
Why the study?
Does maternal cardiac function and morphology differ in pregnancies complicated by intrauterine fetal growth restriction compared to normal pregnancies?
Population
42 nulliparous pregnant women in the third trimester, including 21 with fetuses having intrauterine growth…
Design
Case-control
Authors
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Supports maternal hemodynamic assessment in fetal growth restriction; leaves open therapeutic implications.
Case-Control (n=42)
Does maternal cardiac function and morphology differ in pregnancies complicated by intrauterine fetal growth restriction compared to normal pregnancies?
Absolute Event Rate: 4.6% vs 6.7%
p-value: p=<0.0001
Pregnancies complicated by intrauterine fetal growth restriction are associated with an abnormal maternal cardiovascular compensatory response, characterized by reduced cardiac output, increased vascular resistance, and depressed left atrial function.
Vasapollo et al. (2002) conducted a case-control in Intrauterine fetal growth restriction (n=42). Intrauterine fetal growth restriction (IUGR) pregnancy vs. Normal pregnancy was evaluated on Cardiac output (L) (p=<0.0001). Pregnancies complicated by intrauterine fetal growth restriction were associated with significantly lower maternal cardiac output (4.6 vs 6.7 L) and higher total vascular resistance compared to normal pregnancies.
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