Key result
Pre-eclamptic IUGR was associated with greater impairment in maternal diastolic function compared to normotensive IUGR (DTI early diastolic velocity Z-score -1.6 vs -0.17; P<0.01).
Why the study?
Does maternal cardiac function differ between pregnancies complicated by normotensive versus pre-eclamptic intrauterine growth restriction?
Population
36 pregnant women at 20-38 weeks of gestation, including 19 with normotensive intrauterine growth…
Comparison
Pre-eclamptic intrauterine growth restriction vs Normotensive intrauterine growth restriction
Design
Cross-sectional
Authors
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Hypothesis-generating for differential cardiac phenotypes in IUGR; prospective validation required before any clinical use.
Observational (n=36)
Does maternal cardiac function differ between pregnancies complicated by normotensive versus pre-eclamptic intrauterine growth restriction?
Absolute Event Rate: -1.6% vs -0.17%
p-value: p=<0.01
Pre-eclamptic IUGR is associated with significantly greater impairment in maternal left ventricular diastolic function compared to normotensive IUGR, highlighting the added cardiovascular burden of pre-eclampsia.
Bamfo et al. (2008) conducted an observational in Intrauterine growth restriction (IUGR) (n=36). Pre-eclamptic IUGR vs. Normotensive IUGR was evaluated on DTI early diastolic velocity at the lateral mitral margin (Z-score) (p=<0.01). Pre-eclamptic IUGR was associated with greater impairment in maternal diastolic function compared to normotensive IUGR (DTI early diastolic velocity Z-score -1.6 vs -0.17; P<0.01).
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