What does this research mean for the field?

Copper oxide nanoparticles synthesized using Myrtus communis leaf extract demonstrate significant antibacterial and antifungal activities and are well-tolerated in vivo at lower doses. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize copper oxide nanoparticles using Myrtus communis leaf extract and evaluate their physicochemical characteristics, antimicrobial performance, and in vivo toxicity.

September 10, 2026Preparative Biochemistry & Biotechnology

Eco-friendly synthesis of copper oxide nanoparticles using Myrtus communis L . leaf extract: characterization, antimicrobial activity, and in vivo toxicity evaluation

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Authors

PJParwin J. Jalil BSBushra H. Shnawa RMRenjbar M. Mhammedsharif

Discussion

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Overview

Preclinical evaluation demonstrates potent antimicrobial activity and dose-dependent toxicity of plant-synthesized copper oxide nanoparticles in mice, suggesting biomedical therapeutic potential.

Key Points

To synthesize copper oxide nanoparticles using Myrtus communis leaf extract and evaluate their physicochemical characteristics, antimicrobial performance, and in vivo toxicity.
Synthesized CuO-NPs via green synthesis using Myrtus communis leaves as reducing and stabilizing agents, followed by structural characterization via UV-Vis, FTIR, XRD, SEM, and EDX.
Assayed antibacterial and antifungal efficacy against selected bacterial and fungal pathogens to determine minimum inhibitory concentrations and colony growth inhibition.
Assessed in vivo safety and organ biocompatibility in BALB/c mice using detailed histopathological examinations of kidney and intestinal tissues.
Nanoparticles demonstrated significant antibacterial efficacy, with minimum inhibitory concentrations of 3.125 µg/100 µL against Staphylococcus aureus and 12.5 µg/100 µL against both Klebsiella pneumoniae and Escherichia coli.
Antifungal activity produced marked morphological alterations and suppressed fungal colony growth, reducing Penicillium sp. colony diameter from 77.1 mm in controls to 28.5 mm, with comparable growth inhibition observed in Aspergillus niger and Aspergillus fumigatus.
Histopathological evaluation in BALB/c mice revealed that lower doses were well tolerated without observable tissue damage, whereas higher doses caused histopathological lesions in both kidney and intestinal tissues.

Cite This Study

Jalil et al. (2026) studied this question.

synapsesocial.com/papers/6aa2ae5058559d80afc76175 https://doi.org/10.1080/10826068.2026.2726329

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September 10, 2026Preparative Biochemistry & Biotechnology

Eco-friendly synthesis of copper oxide nanoparticles using Myrtus communis L . leaf extract: characterization, antimicrobial activity, and in vivo toxicity evaluation

View Full Paper

Ask AI

Bookmark

Authors

PJParwin J. Jalil BSBushra H. Shnawa RMRenjbar M. Mhammedsharif

Discussion

Member takes

Overview

Preclinical evaluation demonstrates potent antimicrobial activity and dose-dependent toxicity of plant-synthesized copper oxide nanoparticles in mice, suggesting biomedical therapeutic potential.

Key Points

To synthesize copper oxide nanoparticles using Myrtus communis leaf extract and evaluate their physicochemical characteristics, antimicrobial performance, and in vivo toxicity.
Synthesized CuO-NPs via green synthesis using Myrtus communis leaves as reducing and stabilizing agents, followed by structural characterization via UV-Vis, FTIR, XRD, SEM, and EDX.
Assayed antibacterial and antifungal efficacy against selected bacterial and fungal pathogens to determine minimum inhibitory concentrations and colony growth inhibition.
Assessed in vivo safety and organ biocompatibility in BALB/c mice using detailed histopathological examinations of kidney and intestinal tissues.
Nanoparticles demonstrated significant antibacterial efficacy, with minimum inhibitory concentrations of 3.125 µg/100 µL against Staphylococcus aureus and 12.5 µg/100 µL against both Klebsiella pneumoniae and Escherichia coli.
Antifungal activity produced marked morphological alterations and suppressed fungal colony growth, reducing Penicillium sp. colony diameter from 77.1 mm in controls to 28.5 mm, with comparable growth inhibition observed in Aspergillus niger and Aspergillus fumigatus.
Histopathological evaluation in BALB/c mice revealed that lower doses were well tolerated without observable tissue damage, whereas higher doses caused histopathological lesions in both kidney and intestinal tissues.

Cite This Study

Jalil et al. (2026) studied this question.

synapsesocial.com/papers/6aa2ae5058559d80afc76175 https://doi.org/10.1080/10826068.2026.2726329

View Full Paper

Ask AI

Bookmark