Key result
MRI-based finite element model maps ventricular wall anisotropy to improve understanding of cardiac performance.
The study presents a preparation method and a Finite Element model to analyze the global and local anisotropic structure of human ventricular muscle fibers to better understand cardiac performance.
Model of ventricular anisotropy may refine mechanistic understanding of heart failure; leaves open validation and clinical translation.
An important determinant of cardiac output derives from the structure of the ventricular wall given by the arrangement of the cardiac muscle fibres. A key feature of this arrangement is both a global and local anisotropy. First, a preparation method necessary for analyzing the main aspects of spatial fibre architecture is outlined. Global anisotropy can be described by a gross band-like structure wrapping both left and right ventricles while local anisotropy results from the arrangement of the individual muscle fibres within the band. In pathologic cases this basic structure may be disturbed leading to cardiac failure. Second, a Finite Element model, formulated on the basis of Magnetic Resonance measurements has been devised which is intended to reflect the global as well as the local anisotropy of the ventricles in order to further the understanding of cardiac performance.
No takes yet. Share an insight, caveat, or question.
Schmid et al. (1997) studied Cardiac structure and anisotropy. A Finite Element model based on Magnetic Resonance measurements was developed to reflect the global and local anisotropy of the ventricular wall to further the understanding of cardiac performance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: