Key result
Heparin linked to fatal HIT presenting as venous gangrene and PEA arrest in untreated myeloproliferative neoplasm.
Case Report (n=1)
This case highlights that heparin-induced thrombocytopenia can present atypically as venous limb gangrene and sudden PEA cardiac arrest (anaphylactoid reaction) following a heparin bolus, even in the presence of thrombocytosis due to an underlying myeloproliferative neoplasm.
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Alerts clinicians to atypical HIT risk in myeloproliferative neoplasms; leaves open need for prospective validation before practice change.
Avram et al. (2020) conducted a case report in Venous limb gangrene and PEA cardiac arrest (n=1). Heparin was evaluated. A 55-year-old man with an untreated myeloproliferative neoplasm developed fatal heparin-induced thrombocytopenia presenting as venous limb gangrene and post-heparin bolus PEA cardiac arrest.
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