Key result
Fasudil ameliorates doxorubicin-induced kidney damage and suppresses cellular apoptosis in mice and cell models.
Why the study?
Doxorubicin treatment is limited by side effects, and the study investigated the possible protective effect of the Rho/ROCK inhibitor fasudil on doxorubicin-induced nephrotoxicity.
Does fasudil prevent doxorubicin-induced nephrotoxicity in mice and NRK-52E cells?
Population
Forty male C57BL/6 male mice and NRK-52E cells
Comparison
DOX plus low- or high-dose fasudil vs DOX alone vs saline control
Design
Randomized preclinical in vivo and in vitro study
Follow-up
8 weeks
Authors
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Should not change DOX management; hypothesis-generating for fasudil in chemotherapy nephrotoxicity and requires clinical trials.
Does fasudil prevent doxorubicin-induced nephrotoxicity in mice and NRK-52E cells?
Fasudil protects against doxorubicin-induced nephrotoxicity by inhibiting oxidative stress, DNA damage, apoptosis, and cell senescence via the RhoA/ROCK signaling pathway.
Xiang et al. (2020) studied Doxorubicin-induced nephrotoxicity (n=40). Fasudil vs. Doxorubicin alone and saline control was evaluated on Kidney damage, cell apoptosis, senescence, redox imbalance, and DNA damage. Fasudil ameliorated doxorubicin-induced kidney damage, suppressed cell apoptosis and senescence, and improved redox imbalance and DNA damage in mice and NRK-52E cells.