HR 375, a 3‐(4‐(3‐(4‐fluorobenzoyl)‐propyl‐piperazino‐l‐yl‐isoquinolino‐ hydrochloride is a new compound with marked effects in tests of predictive value for neuroleptic activity. Its pharmacological profile is different from classical neuroleptics. HR 375 has inhibitory activity in apomorphine‐induced climbing, amphetamine aggregation toxicity, Sidman avoidance, and amphetamine‐induced hypermotility. On the other hand, only weak activity is seen in antagonizing amphetamine‐induced stereotypy, apomorphine‐turning, and apomorphine emesis. It does not include catalepsy in rats and cynomolgus monkeys even in high doses. Also, its sedative or muscle relaxant properties are weak and short‐lasting. The psychopharmacological profile of HR 375 indicates a split between its effects on the mesolimbic and nigrostriatal system.
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Hock et al. (1985) studied this question.
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