Key result
IFAT proves more sensitive than xenodiagnosis for detecting Trypanosoma cruzi infection in opossums.
IFAT is a highly sensitive diagnostic test for detecting Trypanosoma cruzi infection in the opossum Didelphis marsupialis.
IFAT may aid T. cruzi reservoir monitoring in opossums; leaves open field validation before any surveillance role.
The use of an indirect fluorescent antibody test (IFAT) performed in a "sandwich" technique has demonstrated: (i) the usefulness of the test for the diagnosis of Trypanosoma cruzi infection in the opossum Didelphis marsupialis; (ii) the existence of differences in the serological response of the opossum, that were related to the parasite strain and were clearly evident during the follow-up of experimental infections in laboratory born specimens; (iii) that, despite a good correlation between serological and parasitological examinations, IFAT was the most sensitive diagnostic test used, followed by xenodiagnosis; and, (iv) that in general, the opossum D. marsupialis seems to be a good responder to T. cruzi antigens.
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Jansen et al. (1985) studied Trypanosoma cruzi infection. Indirect fluorescent antibody test (IFAT) vs. Xenodiagnosis was evaluated on Diagnostic sensitivity for Trypanosoma cruzi infection. An indirect fluorescent antibody test (IFAT) was the most sensitive diagnostic test for Trypanosoma cruzi infection in the opossum Didelphis marsupialis, followed by xenodiagnosis.
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