Key result
Various phytocompounds isolated from natural sources can modulate platelet activation and inhibit adenosine diphosphate-induced platelet aggregation.
Why the study?
Platelets mediate cardiovascular diseases including thrombosis, and compounds or fractions from natural sources may modulate ADP-induced platelet activation and aggregation.
This review highlights the potential of various natural compounds to inhibit ADP-induced platelet aggregation, which may inform the development of novel antiplatelet agents.
Platelets are central in mediating cardiovascular diseases including thrombosis. Aggregation of platelets is an important process following the adhesion of platelets to the injury site which may lead to the formation of a thrombus. Various aspects of platelet activation and aggregation could be modulated with compounds or fractions isolated from natural sources. This review summarizes these natural sources of inhibition against one of the most relevant physiological and pathological platelet agonists-adenosine diphosphate. Reported literature on the subject is further explored to discuss phytocompounds isolated from crude extracts or polarity-based fractions. Structures of the active compounds and their structure-activity relationship are also discussed.
No takes yet. Share an insight, caveat, or question.
Fayed et al. (2021) conducted a review in Cardiovascular diseases including thrombosis. Natural sources of inhibition (phytocompounds) was evaluated on Inhibition of adenosine diphosphate-induced platelet aggregation. Various phytocompounds isolated from natural sources can modulate platelet activation and inhibit adenosine diphosphate-induced platelet aggregation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: