Key result
Chylomicron triglycerides are linked to linearly increased hemoglobin readings, while VLDL triglycerides show no effect.
Why the study?
Does hyperchylomicronemia affect the measurement of hemoglobin and other erythrocyte indices?
Observational (n=26)
Does hyperchylomicronemia affect the measurement of hemoglobin and other erythrocyte indices?
Hyperchylomicronemia can artificially increase hemoglobin readings, which can be corrected by resuspending erythrocytes in saline.
Answers are grounded in this paper and cite their sources.
Chylomicron triglycerides may artifactually elevate hemoglobin readings; leaves open whether saline resuspension warrants routine lab adoption.
The effects of plasma triglyceride levels on the measurement of hemoglobin and other erythrocyte indices have been studied in blood samples from ten healthy controls, 11 patients with type IV hyperlipoproteinemia, and five patients with hyperchylomicronemia (type I or V). Measurements were made using erythrocytes in their own plasmas and repeated after resuspension of the cells in physiologic saline solution. Hemoglobin, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration were decreased by removal of plasma in erythrocytes from three patients with hyperchylomicronemia. It is concluded that the triglyceride contained in very-low-density lipoprotein does not affect hemoglobin measurement, while triglyceride contained in chylomicrons increased hemoglobin readings linearly.
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Gagné et al. (1977) conducted an observational in Hyperchylomicronemia and hyperlipoproteinemia (n=26). Hyperchylomicronemia (plasma triglyceride levels) vs. Healthy controls and type IV hyperlipoproteinemia was evaluated on Hemoglobin measurement. Triglyceride contained in chylomicrons increased hemoglobin readings linearly, while triglyceride in very-low-density lipoprotein did not affect hemoglobin measurement.
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