Stereospecific synthesis of (R)‐[2‐2H1]‐glycine by means of microbial reduction and a determination of It's absolute configuration by CD spectra

A preparation of optically pure (R)‐[2‐2H1]‐glycine by microbial reduction is detailed. The reduction of [2‐2H]‐furfural and furfural with S. Cerevisiae in H2O and in D2O gave (S)‐ and (R)‐Labeled furfuryl alcohol respectively, which could be converted to the labeled glycine in three steps. A new method for the determination of the sense of chirality of the labeled glycine by means of CD spectra and an application of MTPA method for the determination of the optical purity are also described.