Key result
Thoracic epidural anesthesia protected the gut from decreased microvascular perfusion and increased leukocyte-endothelium interaction associated with hemorrhage and retransfusion in an experimental model.
Why the study?
Does thoracic epidural anesthesia improve gut microvascular perfusion and reduce leukocyte-endothelium interaction in a hemorrhage model in rats?
Population
rats in a hemorrhage model
Design
Editorial
Authors
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Should not yet change clinical practice; leaves open translation of experimental gut protection to human hemorrhage.
Does thoracic epidural anesthesia improve gut microvascular perfusion and reduce leukocyte-endothelium interaction in a hemorrhage model in rats?
Thoracic epidural anesthesia may protect against splanchnic hypoperfusion and ischemia-reperfusion injury, though the exact mechanisms require further investigation.
Sielenkämper et al. (2003) conducted an editorial in Splanchnic hypoperfusion and hemorrhage. Thoracic epidural anesthesia (TEA) was evaluated. Thoracic epidural anesthesia protected the gut from decreased microvascular perfusion and increased leukocyte-endothelium interaction associated with hemorrhage and retransfusion in an experimental model.
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