Key result
Mitochondrial disease in women is linked to ~9 mmHg higher SBP than the general population.
Why the study?
Hypertension is more prevalent among patients with mitochondrial diseases, but studies on SBP and DBP in mitochondrial diseases had not yet been performed.
Is systolic blood pressure higher in patients with mitochondrial disease compared to the general population?
Case-Control (n=286)
Is systolic blood pressure higher in patients with mitochondrial disease compared to the general population?
Female patients with mitochondrial disease have significantly higher systolic blood pressure compared to the general population, which is a predictor for left ventricular hypertrophy.
May signal higher LVH risk in women with mitochondrial disease; hypothesis-generating and requires prospective confirmation before practice change.
BACKGROUND: Previous research suggests that hypertension is more prevalent among patients with mitochondrial diseases. Blood pressure (BP) is linearly related to increased cardiovascular risk, and this relationship is strongest for SBP; nevertheless, studies on SBP and DBP in mitochondrial diseases have not yet been performed. METHOD: In a retrospective case-control study design, BP in mitochondrial disease patients was compared with BP in a population cohort. Secondly, using multiple linear regression, we examined blood pressure differences in various genetic mitochondrial diseases. Lastly, we explored additional predictors of BP in a subgroup with the m.3243A > G variant. RESULTS: Two hundred and eighty-six genetically confirmed mitochondrial disease patients were included. One hundred and eighty of these patients carried the m.3243A>G mitochondrial DNA variant. SBP was 9 mmHg higher in female mitochondrial disease patients than in the general female population (95% CI: 4.4-13.3 mmHg, P < 0.001), whereas male patients had similar BP compared with controls. BP was not significantly different in patients with m.8344A>G and m.8363G>A, a mtDNA deletion or a nuclear mutation compared with m.3243A>G patients. Higher SBP was a predictor for left ventricular hypertrophy in the m.3243A>G subgroup (P = 0.04). CONCLUSION: Novel aspects of the role of mitochondrial dysfunction in blood pressure regulation are exposed in this study. Compared with the general population, female mitochondrial disease patients have a higher SBP. Left ventricular hypertrophy is more prevalent in patients with higher SBP. Clinicians should be aware of this to prevent hypertensive complications in mitochondrial disease patients.
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Viering et al. (2022) conducted a case-control in Mitochondrial disease (n=286). Mitochondrial disease vs. General population cohort was evaluated on Systolic blood pressure (SBP) (MD 9, 95% CI 4.4-13.3, p=<0.001). Female patients with mitochondrial disease had a 9 mmHg higher systolic blood pressure compared with the general female population (95% CI: 4.4-13.3; P<0.001).
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