Why the study?
The effects of lifelong exposure to high systolic blood pressure on left ventricular structure and function remained to be estimated using Mendelian randomization.
Does lifelong exposure to higher systolic blood pressure causally increase left ventricular mass and alter left ventricular function in adults?
Does lifelong exposure to higher systolic blood pressure causally increase left ventricular mass and alter left ventricular function in adults?
Mendelian randomization provides genetic evidence for a causal relationship between lifelong higher systolic blood pressure and adverse left ventricular remodeling, specifically increased LV mass and global radial strain.
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Genetically predicted SBP effects on LV remodeling support causality; leaves open whether BP lowering prevents progression in clinical practice.
Hendriks et al. (2019) studied this question.
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