Key result
Higher cumulative systolic BP linked to ~36% higher myocardial scar risk per SD.
Why the study?
This study examined whether decade-long cumulative blood pressure exposure is associated with global and regional myocardial structure and function independent of current blood pressure levels.
Does long-term cumulative blood pressure exposure independently associate with adverse changes in cardiac structure, function, and scarring in adults?
Cohort (n=3,015)
Yes
Does long-term cumulative blood pressure exposure independently associate with adverse changes in cardiac structure, function, and scarring in adults?
Odds Ratio: 1.36 (95% CI 1.02–1.82)
p-value: p=0.012
Long-term cumulative blood pressure exposure is significantly associated with worsened left ventricular structure and function, and increased myocardial scarring, even independently of a single cross-sectional blood pressure measurement.
Supports cumulative SBP exposure assessment for scar risk beyond current BP; extends cross-sectional data but leaves causal inference and practice change open.
AIMS: This study examined the associations between decade-long cumulative blood pressure (BP) exposure and global/regional myocardial structure and function independent of current BP levels. METHODS AND RESULTS: We analysed 3015 adults (aged 69.0 ± 9.2 years) from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent cardiac magnetic resonance (CMR) imaging at Year 10 (Exam 5, 2010-12). Measures included left ventricular (LV) parameters, global/regional myocardial function via tagged CMR, interstitial myocardial fibrosis via T1-mapping measures (native T1 and extracellular volume fraction), and myocardial scar via late gadolinium enhancement. We used cumulative exposure to BP through baseline and up to Exam 5 (millimetres of mercury × year) to represent long-term exposure to BP levels. Linear regression, logistic regression, and generalized additive models were used to quantify the association of cumulative BP parameters with measures of cardiac structure and function. Higher cumulative systolic BP (SBP), independent of current SBP, correlated with increased LV mass index [1.93 g/m2 per standard deviation (SD)], worse global/regional circumferential strain (0.24-0.38% lower absolute values per SD), and greater myocardial scar risk [odds ratio (OR): 1.36, 95% confidence interval (CI): 1.02-1.82 per SD]. Cumulative diastolic BP (DBP) was associated with circumferential strain, showing nearly J-shaped relationships after adjusting for current DBP (all P < 0.05). In non-hypertensive individuals with BP consistently below the hypertension threshold, cumulative SBP remained significantly associated with LV mass index and strain but not myocardial scar (OR: 1.53, 95% CI: 0.82-2.87, P = 0.19). CONCLUSION: Higher cumulative BP was associated with worse global and regional cardiac structure/function and myocardial scar, independent of a single BP at the time of imaging, and was still observed to some extent in non-hypertensive individuals who consistently maintained BP levels below the hypertension threshold.
No takes yet. Share an insight, caveat, or question.
Masrouri et al. (2025) conducted a cohort in Free of clinical cardiovascular disease at baseline (n=3,015). Cumulative blood pressure exposure (systolic and diastolic) vs. Lower cumulative blood pressure exposure was evaluated on Myocardial scar risk per standard deviation increase in cumulative systolic blood pressure (OR 1.36, 95% CI 1.02-1.82, p=0.012). Higher decade-long cumulative systolic blood pressure was associated with a 36% increased risk of myocardial scar (OR 1.36) and worsened cardiac structure and function, independent of current blood pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: