Key result
Age does not modify electrophysiological characteristics or dangerous conduction risk in asymptomatic WPW.
Why the study?
Does age modify the electrophysiological characteristics and risk of dangerous forms of WPW in patients with asymptomatic Wolff-Parkinson-White syndrome?
Observational (n=92)
Does age modify the electrophysiological characteristics and risk of dangerous forms of WPW in patients with asymptomatic Wolff-Parkinson-White syndrome?
Age does not modify the electrophysiological risk profile in asymptomatic WPW, suggesting that elderly patients remain at risk and warrant systematic evaluation.
Does not support age-based deferral of evaluation in asymptomatic WPW; leaves open need for prospective risk-stratification trials.
Sudden death might be the first event in patients with asymptomatic WPW. The purpose of the study was to know if the age of the patient modifies the electrophysiological characteristics of asymptomatic WPW. Transesophageal stimulation was performed on 92 asymptomatic WPW patients from the following age groups: 10-69 years (n = 14), 20-29 years (n = 33), 30-39 years (n = 15), 40-49 years (n = 17), and 50-69 years (n = 13). The procedure consisted of atrial pacing up to the second AV block, programmed atrial stimulation using one and two extrastimuli delivered on two driven rhythms in the control state, and after infusion of isoproterenol. In thefive age groups, paroxysmal junctional tachycardia occurred, respectively, in 1 (7%), 1 (3%), 2 (13%), 2 (12%) patients, and not at all in the oldest group. AF > 1 minute occurred, respectively, in 3 (21%), 9 (27%), 5 (33%), 3 (18%), and 4 (31%) patients. The dangerous form of WPW (rapid conduction in the Kent bundle > 240/min in the control state or > 300/min after isoproterenol + AF induction) occurred, respectively, in 3 (21%), 9 (27%), 4 (27%), 1 (6%), and 3 (23%) patients. In conclusion, electrophysiological data of asymptomatic WPW are not modified by age of the patient. Elderly patients remain at risk of a dangerous form of WPW; systematic evaluation of WPWis recommended in patients with an active life independent of age.
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Brembilla-Perrot et al. (2001) conducted an observational in Asymptomatic Wolff-Parkinson-White (WPW) syndrome (n=92). Age vs. Different age groups was evaluated on Dangerous form of WPW (rapid conduction in the Kent bundle > 240/min in the control state or > 300/min after isoproterenol + AF induction). Age does not modify the electrophysiological characteristics of asymptomatic WPW, with the dangerous form occurring in 6% to 27% of patients across age groups from 10 to 69 years.
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