Key result
Impaired cellular protein homeostasis and loss of quality control drive cardiac disease onset.
Highlights the theoretical role of proteostasis derailment and loss of protein quality control in the onset of cardiac diseases.
May inform proteostasis-targeted therapies; leaves open clinical translation pending prospective trials.
The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of the protein quality control as central factors. In the heart, loss of protein patency, due to flaws in design (genetically) or environmentally-induced wear and tear, may overwhelm protein quality control, thereby triggering derailment of proteostasis and contributing to cardiac disease onset.
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Bianca J.J.M. Brundel (2020) conducted a review in Cardiac diseases. Proteostasis derailment was evaluated. Derailment of cellular protein homeostasis and loss of protein quality control are central factors contributing to the onset of cardiac diseases.
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