Key result
A loading dose of 50 microg/kg of milrinone resulted in a mean decrease in mean blood pressure of 12% and a mean increase in cardiac index of 18% at a mean peak plasma concentration of 235 ng/ml.
Why the study?
What are the pharmacokinetics and hemodynamic effects of a milrinone loading dose in children after cardiac surgery?
Population
20 children after repair of congenital cardiac defects
Design
Cohort
Follow-up
16 hours
Authors
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May support milrinone loading-dose use in post-surgical children; extends pediatric PK data but leaves optimal regimens open for randomized confirmation.
What are the pharmacokinetics and hemodynamic effects of a milrinone loading dose in children after cardiac surgery?
A 50 microg/kg loading dose of milrinone effectively increases cardiac index in pediatric patients after cardiac surgery, with maintenance infusion requirements dependent on age.
Bailey et al. (1999) studied Congenital cardiac defects post-surgery (n=20). Milrinone was evaluated on Pharmacokinetics and hemodynamic changes (mean blood pressure and cardiac index). A loading dose of 50 microg/kg of milrinone resulted in a mean decrease in mean blood pressure of 12% and a mean increase in cardiac index of 18% at a mean peak plasma concentration of 235 ng/ml.
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