Key points are not available for this paper at this time.
. We also discuss the functional importance of ZBP1-RIPK3 signaling in recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viral infections. Understanding these mechanisms of RNA virus-induced cytopathic and pathogenic inflammatory responses is crucial for targeting pathogenic lung infections and human respiratory illness.
Basavaraju et al. (2022) studied this question. ZBP1 and ZBP1-RIPK3 signaling mediate Z-RNA sensing, virus-induced cell death, and pathogenic pulmonary inflammation during influenza and SARS-CoV-2 infections.