May 1, 1991Clinical Science
Skeletal muscle degradation and nitrogen wasting in rats with chronic metabolic acidosis
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Discussion
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Implication
Controlled animal study demonstrates accelerated skeletal muscle catabolism and nitrogen wasting in acidotic rats, suggesting muscle breakdown fuels renal ammoniagenesis.
Key Points
- To examine in vivo the effects of chronic metabolic acidosis on growth, nitrogen balance, and skeletal muscle catabolism.
- Assessed growth, nitrogen utilization, and body mass acquisition in rats with induced chronic metabolic acidosis relative to pair-fed controls.
- Tracked total nitrogen excretion, urea production rates, and the time course of skeletal muscle protein catabolism.
- Acidotic animals exhibited significantly impaired growth, reduced nitrogen utilization, and decreased body mass acquisition compared to pair-fed controls.
- Total nitrogen excretion increased significantly in acidotic rats despite a down-regulation of urea production, synchronizing with accelerated skeletal muscle protein breakdown.
Cite This Study
Williams et al. (1991) studied this question.