Key result
FAP patients and asymptomatic carriers show depressed vasoconstrictive responses vs controls, indicating early autonomic dysfunction.
Why the study?
Are autonomic nerve functions impaired in patients with familial amyloidotic polyneuropathy and asymptomatic carriers compared to healthy controls?
Cross-Sectional
Are autonomic nerve functions impaired in patients with familial amyloidotic polyneuropathy and asymptomatic carriers compared to healthy controls?
Autonomic nervous system dysfunction, as measured by laser Doppler flowmetry and R-R interval analysis, is detectable in the very early stages of familial amyloidotic polyneuropathy, even in asymptomatic carriers.
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May support early autonomic testing in FAP carriers; hypothesis-generating and requires prospective validation before clinical use.
Araki et al. (1992) conducted a cross-sectional in Familial amyloidotic polyneuropathy. Familial amyloidotic polyneuropathy (FAP) and asymptomatic carrier status vs. Healthy controls was evaluated on Vasoconstrictive responses induced by deep inspiration. Vasoconstrictive responses to deep inspiration were depressed in 11 FAP patients and 3 of 4 asymptomatic carriers compared with healthy controls, indicating early autonomic dysfunction.
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