Key result
The ACE2 A/A genotype was significantly associated with increased susceptibility to COVID-19 in Egyptian children and adolescents (44% vs 30%; OR 2.83; 95% CI 1.27-2.63; p=0.006).
Why the study?
The ACE2 gene has emerged as a potential candidate gene for SARS-CoV-2 susceptibility, but its role in Egyptian children and adolescents was unconfirmed.
Does the ACE2 G8790A polymorphism increase susceptibility to COVID-19 and disease severity in Egyptian children and adolescents?
Case-Control (n=1,160)
Does the ACE2 G8790A polymorphism increase susceptibility to COVID-19 and disease severity in Egyptian children and adolescents?
Odds Ratio: 2.83 (95% CI 1.27–2.63)
Absolute Event Rate: 44% vs 30%
p-value: p=0.006
The ACE2 G8790A polymorphism, specifically the A/A genotype, is associated with increased susceptibility to COVID-19, while the G/G genotype is an independent risk factor for severe disease in Egyptian children.
ACE2 rs2285666 variants were associated with pediatric COVID-19 susceptibility and severity; leaves open replication before any clinical genetic testing.
OBJECTIVE: Recently, angiotensin-converting enzyme 2 (ACE2) gene has emerged as a potential candidate gene for susceptibility to SARS-CoV-2 infection. We investigated whether ACE2 G8790A (rs2285666) polymorphism could be a genetic marker for susceptibility to COVID-19 and disease severity in Egyptian children and adolescents. METHODS: This was a prospective case-control study included 580 cases diagnosed with COVID-19, and 580 matched control children and adolescents. The ACE2 G8790A (rs2285666) polymorphism was genotyped using polymerase chain reaction (PCR) and ACE2 serum level was measured by ELISA. RESULTS: The ACE2 A/A genotype and A-allele were significantly more represented in cases with COVID-19 as compared to control group (44% vs. 30%; OR = 2.83; [95% CI: 1.27-2.63]; p = 0.006; for the A/A genotype) and (65% vs. 51%; OR = 1.9; [95% CI: 1.06-1.72]; p = 0.01; for the A-allele). The presence of ACE2 G/G genotype was an independent risk factor for severe disease (adjusted OR: 2.08; [95% CI: 1.57-6.78]; p = 0.003). CONCLUSION: The ACE2 G8790A (rs2285666) polymorphism may confer susceptibility to COVID-19 in Egyptian children and adolescents. The ACE2 G/G genotype and G-allele was associated with lower ACE2 serum levels and may constitute independent risk factors for disease severity.
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Ibraheem et al. (2025) conducted a case-control in COVID-19 (n=1,160). ACE2 G8790A (rs2285666) A/A genotype vs. Control group was evaluated on COVID-19 susceptibility (OR 2.83, 95% CI 1.27-2.63, p=0.006). The ACE2 A/A genotype was significantly associated with increased susceptibility to COVID-19 in Egyptian children and adolescents (44% vs 30%; OR 2.83; 95% CI 1.27-2.63; p=0.006).
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