Further evidence for the location of the BPES gene at 3q2.

Nilbert et al3 reported a uterine leio- myosarcoma with a t(8;13).In addition, several uterine leiomyomas with structural or numerical abnormalities of chromosome 8 were reported by Mark et a14 and Teyssier and Ferre.5 Especially interesting in relation to the case under discussion is the latter authors' report of trisomy 8 in another gastrointestinal smooth muscle tu- mour, an oesophageal leiomyoma.Thus, the abnormalities in chromo- some 8 in smooth muscle tumours described so far involve both numer- ical and structural abnormalities and concern both benign and malignant tumours.We think that these data give a different perspectiVe to the dis- cussion of the case reported by Les- sick et al.