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Nineteen patients with generalized lymphoma were treated with large intermittent intravenous doses of cyclophosphamide. Five patients experienced a complete response, and 2 had a partial response. The median duration of complete response was 22 months. Toxicity was not intolerable. Published results of response rates in lymphoma to various chemotherapeutic agents are summarized. Factors which contribute to survival in patients with lymphoma are discussed. It is suggested that further evaluation of large intermittent doses of cyclophosphamide be made in view of the favorable results.
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Mendelson et al. (1970) studied this question.
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