Key result
Perioperative intravenous sildenafil significantly reduced mean extubation time (7.0 vs 22.1 hours) and postoperative ICU stay (42.3 vs 64.4 hours) in children with congenital heart disease and pulmonary hypertension.
Why the study?
Does perioperative intravenous sildenafil improve physiological parameters and reduce extubation time and ICU stay in children with ventricular septal defects and pulmonary hypertension undergoing cardiac surgery?
RCT (n=46)
Open-label
Randomly generated chits in sealed envelopes
No
Does perioperative intravenous sildenafil improve physiological parameters and reduce extubation time and ICU stay in children with ventricular septal defects and pulmonary hypertension undergoing cardiac surgery?
Absolute Event Rate: 7% vs 22.1%
p-value: p=<0.05
Perioperative intravenous sildenafil improves oxygenation and hemodynamics, and reduces extubation time and ICU stay in children with VSD and pulmonary hypertension undergoing cardiac surgery.
Perioperative IV sildenafil shortens extubation and ICU stay in children with VSD-PH; extends RCT evidence for targeted PH management in congenital heart surgery.
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Sharma et al. (2015) conducted an RCT in Congenital heart disease with pulmonary hypertension (n=46). Intravenous sildenafil vs. Standard care (no sildenafil) was evaluated on Extubation time (hours) (p=<0.05). Perioperative intravenous sildenafil significantly reduced mean extubation time (7.0 vs 22.1 hours) and postoperative ICU stay (42.3 vs 64.4 hours) in children with congenital heart disease and pulmonary hypertension.
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